000128064 001__ 128064
000128064 037__ $$aIKEECONF-2011-031
000128064 040__ $$aAristotle University of Thessaloniki
000128064 041__ $$aeng
000128064 100__ $$aLoukopoulos, Panayiotis
000128064 245__ $$aEnzootic nasal tumour of sheep and goats in Cyprus and Greece.
000128064 520__ $$aIntroduction. The enzootic nasal tumour (ENT) of sheep and goats arises from the ethmoid turbinate following infection by exogenous retroviruses ENTV -1 and -2, respectively, and is usually classified as an adenoma or low grade adenocarcinoma. The geographical distribution of the disease is believed to be wide but has not been studied comprehensively. Materials and Methods. 42 tumours of sheep were examined, 17 of which were from Cyprus and 25 from Greece, the first of which were initially diagnosed in 1996 and 1991 respectively. Tumours of goats that were included in the study were retrieved from the archives or were recruited as part of an ongoing prospective study. 54 goat ENTs were examined, the first of which was initially examined in 1984.  The tumours were examined grossly and microscopically and a selected number of tumour samples was analysed using PCR and sequencing. Results. The sheep ENTs originated from two regions in Cyprus (Larnaca and Paphos) and from north Greece. Although no metastases were observed, most Cypriot sheep tumours were locally aggressive carcinomas, with 14/17 presenting with exophthalmos, while the Greek cases presented a wider range of lesions, in two cases presenting as hyperplasia/dysplasia and were overall of lower grade. The goat ENTs originated from north and central Greece, but were absent in Cyprus. A small number of goat ENTs was locally aggressive. Histologically, most cases were low grade adenocarcinomas. PCR detected ENTV-1 and -2 proviral DNA within the sheep and goat tumours examined, respectively. Sequencing and phylogenetic analysis demonstrated clustering of the goat  isolates with the ENTV -2 prototypes in branches distinct from the sheep isolates as well as ENTV-1, JSRV and SERV representatives. Conclusions. ENT of sheep is present and appears to have widespread geographical distribution in Cyprus and Greece. ENT cases from Cyprus appear to be of markedly higher grade. The disease in goats is widespread in Greece but absent in Cyprus. Further examination and monitoring of the disease status is warranted.
000128064 611__ $$aEuropean Conference in Small Ruminant Health Management, European College of Small Ruminant Health Management$$cAthens, Greece$$d29/10/2011-30/10/2011$$ghttp://www.ecsrhm.eu
000128064 653__ $$aENTV-1
000128064 653__ $$aENTV-2
000128064 653__ $$aSheep
000128064 653__ $$aGoats
000128064 653__ $$aPathology
000128064 653__ $$aCancer
000128064 653__ $$aΑίγες
000128064 653__ $$aΠρόβατα
000128064 653__ $$aΠαθολογική ανατομική
000128064 653__ $$aΚαρκίνος
000128064 700__ $$aΛουκόπουλος, Παναγιώτης
000128064 700__ $$aIoannou, I.
000128064 700__ $$aDovas, C.I. 
000128064 700__ $$aPsychas, V. 
000128064 700__ $$aKonstantinou, P. 
000128064 700__ $$aGeorgiadou, S. 
000128064 700__ $$aApostolidi, E. 
000128064 700__ $$aKaldrymidou, E.
000128064 700__ $$aGiadinis, N.D. 
000128064 700__ $$aΙωάννου, Ιωάννης
000128064 700__ $$aΔόβας, Χρυσόστομος 
000128064 700__ $$aΨύχας, Β.
000128064 700__ $$aΚωνσταντίνου, Π.
000128064 700__ $$aΓεωργιάδου, Σ.
000128064 700__ $$aΑποστολίδη, Ευαγγελία 
000128064 700__ $$aΚαλδρυμίδου, Ελένη
000128064 700__ $$aΓιαδίνης, Νεκτάριος Δ.
000128064 710__ $$aΑριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης$$bΚτηνιατρική Σχολή
000128064 773__ $$d$$g[2011] p.35-35$$nPublished Version$$o$$tAbstract booklet, European Conference in Small Ruminant Health Management, European College of Small Ruminant Health Management$$x
000128064 909CO $$ooai:invenio.lib.auth.gr:128064$$pIKEECONF
000128064 980__ $$aIKEE
000128064 980__ $$aIKEECONF
000128064 990__ $$aOriginally submitted by plouk on Mon, 21 Nov 2011$$d201111211457$$m11$$t1321880265$$y2011
000128064 991__ $$aApproved and Edited by ekarkani on Mon, 21 Nov 2011$$d201111211523$$m11$$t1321881827$$y2011